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CV

Curriculum vitae

for

Anne Thoustrup Saber


Education

2010 Project Management course (Implement)
2006 Ph. D. degree in health sciences from University of Copenhagen
1996 MSc in Human Biology from University of Copenhagen
1993 Bachelor of Science in Chemical Engineering from Engineering Academy of Denmark

Positions

2009- Senior Researcher at the National Research Centre for the Working Environment, Copenhagen, Denmark
2007 Post doc at Institute for Cellular and Molecular Medicine at the University of Copenhagen.
2006-2009 Post doc at the National Institute of Occupational Health
2000-2005 Ph. D. student at the National Institute of Occupational Health
1999-2000 Academic employee at the Danish Medicines Agency
1998 Research assistant at the National Institute of Occupational Health
1997 Research assistant at the Technical University of Denmark

Administrative Experience

2013- WP leader and project leader on the NFA part of the Danish EPA project Consumer exposure and risk assessment of nanomaterials in products on the Danish market
2010-2013 WP leader and project leader on the NRCWE part of the FP7 research project NanoSustain ((http://www.nanosustain.eu/)
2009-2011 Project leader of the research project NANOKEM  (http://www.arbejdsmiljoforskning.dk/da/projekter/nanopartikler-i-farve-og-lakindustrien---nanokem)(2007-2011)

Honorary offices

2009- Appointed as a member of the corps of external examiners of the Danish engineering education (subject area Chemistry).
2008- Member of the Nordic Expert Group (NEG): Danish representative

Reviewer

Reviewer for: Nanotoxicology, Particle & Fibre Toxicology, Human & Experimental Toxicolog, Toxics. Reviewer of criteria documents for the Nordic Expert Group (NEG).

Publications

Articles in international peer reviewed journals

29. Stone V, Pozzi-Mucelli S, Tran L, Aschberger K, Sabella S, Vogel U, Poland C, Balharry D, Fernandes T, Gottardo S, Hankin S, Hartl MG, Hartmann N, Hristozov D, Hund-Rinke K, Johnston H, Marcomini A, Panzer O, Roncato D, Saber AT, Wallin H, and Scott-Fordsmand JJ. (2014). ITS-N. Part Fibre.Toxicol. 11 (1): 9.
28. Kobler C, Saber AT, Jacobsen NR, Wallin H, Vogel U, Qvortrup K, and Molhave K. (2014). FIB-SEM imaging of carbon nanotubes in mouse lung tissue. Anal.Bioanal.Chem.
27. Sos PS, Jacobsen NR, Labib S, Wu D, Husain M, Williams A, Bogelund JP, Andersen O, Kobler C, Molhave K, Kyjovska ZO, Saber AT, Wallin H, Yauk CL, Vogel U, and Halappanavar S. (2013). Transcriptomic analysis reveals novel mechanistic insight into murine biological responses to multi-walled carbon nanotubes in lungs and cultured lung epithelial cells. PLoS.One. 8 (11): e80452.
26. Jackson P, Pedersen LM, Kyjovska ZO, Jacobsen NR, Saber AT, Hougaard KS, Vogel U, and Wallin H. (2013). Validation of freezing tissues and cells for analysis of DNA strand break levels by comet assay. Mutagenesis 28 (6): 699-707.
25. Bourdon JA, Saber AT, Jacobsen NR, Williams A, Vogel U, Wallin H, Halappanavar S, and Yauk CL. (2013). Carbon black nanoparticle intratracheal instillation does not alter cardiac gene expression. Cardiovasc.Toxicol. 13 (4): 406-412.
24. Saber AT, Lamson JS, Jacobsen NR, Ravn-Haren G, Hougaard KS, Nyendi AN, Wahlberg P, Madsen AM, Jackson P, Wallin H, Vogel U. Particle-induced pulmonary acute phase response correlates with neutrophil influx linking inhaled particles and cardiovascular risk.PLoS One. 2013 Jul 24;8(7):e69020. doi: 10.1371/journal.pone.0069020. Print 2013.
23. Hougaard KS, Jackson P, Kyjovska ZO, Birkedal RK, De Temmerman PJ, Brunelli A, Verleysen E, Madsen AM, Saber AT, Pojana G, Mast J, Marcomini A, Jensen KA, Wallin H, Szarek J, Mortensen A, Vogel U. Effects of lung exposure to carbon nanotubes on female fertility and pregnancy. A study in mice. Reprod Toxicol. 2013 May 25. doi:pii: S0890-6238(13)00108-1. 10.1016/j.reprotox.2013.05.006. [Epub ahead of print]
22. Husain M, Saber AT, Guo C, Jacobsen NR, Jensen KA, Yauk CL, Williams A, Vogel U, Wallin H, Halappanavar S: Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation.Toxicol Appl Pharmacol. 2013 Jun 15;269(3):250-62. doi: 10.1016/j.taap.2013.03.018. Epub 2013 Apr 1.
21. Bourdon JA, Saber AT, Halappanavar S, Jackson PA, Wu D, Hougaard KS, Jacobsen NR, Williams A, Vogel U, Wallin H, Yauk CL: Carbon black nanoparticle intratracheal installation results in large and sustained changes in the expression of miR-135b in mouse lung. Environ Mol Mutagen. 2012 Jul;53(6):462-8. doi: 10.1002/em.21706. Epub 2012 Jun 29.
20. Bourdon JA, Halappanavar S, Saber AT, Jacobsen NR, Williams A, Wallin H, Vogel U, Yauk CL: Hepatic and pulmonary toxicogenomic profiles in mice intratracheally instilled with carbon black nanoparticles reveal pulmonary inflammation, acute phase response, and alterations in lipid homeostasis.Toxicol Sci. 2012 Jun;127(2):474-84. doi: 10.1093/toxsci/kfs119. Epub 2012 Mar 29.
19. Bourdon JA, Saber AT, Jacobsen NR, Jensen KA, Madsen AM, Lamson JS, Wallin H, Møller P, Loft S, Yauk CL, Vogel UB: Carbon black nanoparticle instillation induces sustained inflammation and genotoxicity in mouse lung and liver. Part Fibre Toxicol. 2012 Feb 2;9:5. doi: 10.1186/1743-8977-9-5.
18. Saber AT, Jacobsen NR, Mortensen A, Szarek J, Jackson P, Madsen AM, Jensen KA, Koponen IK, Brunborg G, Gützkow KB, Vogel U, Wallin H: Nanotitanium dioxide toxicity in mouse lung is reduced in sanding dust from paint.Part Fibre Toxicol. 2012 Feb 2;9:4. doi: 10.1186/1743-8977-9-4.
17. Mikkelsen L, Jensen KA, Koponen IK, Saber AT, Wallin H, Loft S, Vogel U, Møller P: Cytotoxicity, oxidative stress and expression of adhesion molecules in human umbilical vein endothelial cells exposed to dust from paints with or without nanoparticles. Nanotoxicology. 2013 Mar;7(2):117-34. doi: 10.3109/17435390.2011.641604. Epub 2012 Jan 20.
16. Mikkelsen L, Sheykhzade M, Jensen KA, Saber AT, Jacobsen NR, Vogel U, Wallin H, Loft S, Møller P: Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO(2). Part Fibre Toxicol. 2011 Nov 10;8:32. doi: 10.1186/1743-8977-8-32.
15. Saber AT, Koponen IK, Jensen KA, Jacobsen NR, Mikkelsen L, Møller P, Loft S, Vogel U, Wallin H: Inflammatory and genotoxic effects of sanding dust generated from nanoparticle-containing paints and lacquers.Nanotoxicology. 2012 Nov;6(7):776-88. doi: 10.3109/17435390.2011.620745. Epub 2011 Oct 13.
14. Saber AT, Jensen KA, Jacobsen NR, Birkedal R, Mikkelsen L, Møller P, Loft S, Wallin H, Vogel U: Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers. Nanotoxicology. 2012 Aug;6(5):453-71. doi: 10.3109/17435390.2011.587900. Epub 2011 Jun 7.
13. Jacobsen NR, White PA, Gingerich J, Møller P, Saber AT, Douglas GR, Vogel U, Wallin H: Mutation spectrum in FE1-MUTA(TM) Mouse lung epithelial cells exposed to nanoparticulate carbon black. Environ Mol Mutagen. 2011 May;52(4):331-7. doi: 10.1002/em.20629. Epub 2010 Oct 20.
12. Vogel U, Segel S, Dethlefsen C, Tjønneland A, Saber AT, Wallin H, Jensen MK, Schmidt EB, Andersen PS, Overvad K: Associations between COX-2 polymorphisms, blood cholesterol and risk of acute coronary syndrome. Atherosclerosis. 2010 Mar;209(1):155-62. doi: 10.1016/j.atherosclerosis.2009.08.036. Epub 2009 Aug 28.
11. Vogel U, Segel S, Dethlefsen C, Tjønneland A, Saber AT, Wallin H, Jensen MK, Schmidt EB, Andersen PS, Overvad K: PPARgamma Pro12Ala polymorphism and risk of acute coronary syndrome in a prospective study of Danes. BMC Med Genet. 2009 Jun 7;10:52. doi: 10.1186/1471-2350-10-52.
10. Hougaard KS, Saber AT, Jensen KA, Vogel U, Wallin H: Diesel exhaust particles: effects on neurofunction in female mice. Basic Clin Pharmacol Toxicol. 2009 Aug;105(2):139-43. doi: 10.1111/j.1742-7843.2009.00407.x. Epub 2009 Mar 27. No abstract available.
9. Saber AT, Halappanavar S, Folkmann JK, Bornholdt J, Boisen AM, Møller P, Williams A, Yauk C, Vogel U, Loft S, Wallin H: Lack of acute phase response in the livers of mice exposed to diesel exhaust particles or carbon black by inhalation. Part Fibre Toxicol. 2009 Apr 20;6:12. doi: 10.1186/1743-8977-6-12.
8. Madsen AM, Saber AT, Nordly P, Sharma AK, Wallin H, Vogel U: Inflammation but no DNA (deoxyribonucleic acid) damage in mice exposed to airborne dust from a biofuel plant. Scand J Work Environ Health. 2008 Aug;34(4):278-7.
7. Hougaard KS, Jensen KA, Nordly P, Taxvig C, Vogel U, Saber AT, Wallin H: Effects of prenatal exposure to diesel exhaust particles on postnatal development, behavior, genotoxicity and inflammation in mice. Part Fibre Toxicol. 2008 Mar 11;5:3. doi: 10.1186/1743-8977-5-3.
6. Bornholdt J, Saber AT, Sharma AK, Savolainen K, Vogel U, Wallin H: Inflammatory response and genotoxicity of seven wood dusts in the human epithelial cell line A549. Mutat Res. 2007 Aug 15;632(1-2):78-88. Epub 2007 May 21.
5. Jacobsen NR, Saber AT, White P, Møller P, Pojana G, Vogel U, Loft S, Gingerich J, Soper L, Douglas GR, Wallin H. Increased mutant frequency by carbon black, but not quartz, in the lacZ and cII transgenes of muta mouse lung epithelial cells. Environ Mol Mutagen. 2007 Jul;48(6):451-61.
4. Saber AT, Jacobsen NR, Bornholdt J, Kjaer SL, Dybdahl M, Risom L, Loft S, Vogel U, Wallin H: Cytokine expression in mice exposed to diesel exhaust particles by inhalation. Role of tumor necrosis factor. Part Fibre Toxicol. 2006 Feb 20;3:4.
3. Saber AT, Bornholdt J, Dybdahl M, Sharma AK, Loft S, Vogel U, Wallin H: Tumor necrosis factor is not required for particle-induced genotoxicity and pulmonary inflammation. Arch Toxicol. 2005 Mar;79(3):177-82. Epub 2004 Nov 11.
2. Saber AT, Nielsen LR, Dictor M, Hagmar L, Mikoczy Z, Wallin H: K-ras mutations in sinonasal adenocarcinomas in patients occupationally exposed to wood or leather dust. Cancer Lett. 1998 Apr 10;126(1):59-65.
1. Wallin H, Jørgensen AT, Nielsen LR, Anderson M, Visfeldt J, Vyberg M, Storm HH: Low frequency of point mutations in the K-ras and p53 genes in lung tumors from patients injected with Thorotrast. Radioprotection. 1997; 32 (C1): 251-252.

Reports and book chapters

7. Jensen KA and Saber AT: Chapter 19: Case study scenario: Paints and lacquers with silica nanoparticles in Safety of Nanomaterials along their Lifecycle: Release, Exposure and Human Hazards", Eds. W. Wohlleben, T. Kuhlbusch, C.-M. Lehr, J. Schnekenburger, Taylor & Francis 2014, ISBN 978-1-46-656786-3, 380 pages (in press)
6. Kristensen HV, Hansen SB, Holm GR, Jensen KA, Koponen IK, Saber AT, Nielsen SH, Wallin H: Nanopartikler i Arbejdsmiljøet. Viden og inspiration om håndtering af nanomaterialer. Published by Industriens Branchearbejdsmiljøråd, Branchearbejdsmiljørådet for Undervisning og Forskning, Universitets-og Bygningsstyrelsen, 2010, ISBN: 978-87-92141-28-6.
5. Saber AT and Hougaard KS: Isoflurane, desflurane and sevoflurane. The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals. Arbete och Hälsa. Vetenskaplig skriftserie. Nr 2009; 43(9).
4. Saber AT, Vogel U, Loft S, Wallin H: Particle Induced Cancer. Encyclopedia of Cancer. Schwab, Manfred (Ed.), 2nd ed. 2009, Springer, ISBN: 978-3-540-36847-2.
3. Saber AT: Particle-induced inflammation and DNA damage in mouse models. Ph.d. report, 2006.
2. Saber AT, Vogel U og Wallin H: Risikovurdering af kræftfremkaldende stoffer i arbejdsmiljøet. Rapport til Arbejdstilsynet, 2001.
1. Brandorff NP, Hansen L, Nielsen KM, Knudsen LE, Saber AT og Wallin H: Kritisk gennemgang af den danske liste over stoffer, som anses for at være kræftfremkaldende, og sammenligning med andre nationale og internationale kræftlister./Forslag til inddeling efter styrke af de arbejdsmiljørelevante stoffer. Arbejdsmiljøinstituttet, juni 1999.

Teaching

2009- Course responsible for the laboratory course “Inflammatory and genotoxic effects of nanoparticles” at the environmental chemistry and health education
2009- Occasional lectures in risk assessment and nanotoxicology at the environmental chemistry and health education
2006-2008 Lecture on “Occupational cancer” in the course ‘Toksikologi og arbejdsmiljø’, Danmarks Farmaceutiske Universitet

Supervision

Supervision of 4 master students: Pernille Nordly (DTU), Jacob Stuart Lamson (RUC), Allen Nyendi (RUC) and Sarah Søs Poulsen (RUC).

Supervison of 1 PhD student: Justyna Swietek 2012- (DTU)

External Examinor/Opponent

Censor at DTU course Food Safety in the production chain (2010- ).

PhD opponent

2013:   Opponent for Lise Vesterdal (University of Copenhagen)


 14.03.2014
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