Per Axel Clausen

Forskningsinteresser

Karakterisering og modellering af konventionelle og nanoteknologiske kemiske eksponeringer og emissioner fra forskellige kilder i arbejdsmiljøet, primært ved anvendelse af massespektrometriske teknikker.

Igangværende projekter

NANOPLAST

Center for Indeklima og Sundhed i Boliger (CISBO)

Udvalgte publikationer

Wolkoff P., Clausen P.A., Larsen S.T., Hammer M. and Nielsen G.D. (2012) Airway effects of repeated exposures to ozone-initiated limonene oxidation products as model of indoor air mixtures. Toxicology Letters 209, 166-172.

Clausen P.A., Liu Z., Kofoed-Sørensen V., Little J.C. and Wolkoff P. (2012) The influence of temperature on the emission of di (2 ethylhexyl)phthalate (DEHP) from PVC flooring in the emission cell FLEC. Environmental Science & Technology 46, 909-915.

Palomäki J., Välimäki E., Sund J., Vippola M., Clausen P.A., Jensen K.A., Savolainen K., Matikainen S. and Alenius H. (2011) Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism. ACS Nano 5, 6861-6870.

Clausen P.A., Jacobsen N.R., Jensen K.A., Høg Lejre A.-L., Bøgelund J., Nørgaard A.W., Vibenholt A., Koponen I.K., Birkedal R.K., Møller P., Loft S., Wallin H. and Vogel U. (2010) NANOPLAST: Nano-technological materials and products in the plastics industry: Exposure assessment and toxicological properties. Modern Polymeric Materials for Environmental Applications 4, 53-60.

Clausen P.A., Liu Z., Xu Y., Kofoed-Sørensen V. and Little J.C. (2010) Influence Of Air Flow Rate On Emission Of DEHP From Vinyl Flooring In The Emission Cell FLEC: Measurements And CFD Simulation. Atmospheric Environment 44, 2760-2766.

Nørgaard A.W., Jensen K.A., Janfeldt C., Lauritsen F.R., Clausen P.A. and Wolkoff P. (2009) Release of VOCs and Particles During Use of Nanofilm Spray Products. Environ.Sci.Technol. 43, 7824-7830.

Vibenholt A., Nørgaard A.W., Clausen P.A. and Wolkoff P. (2009) Formation and stability of secondary ozonides from monoterpenes studied by mass spectrometry. Chemosphere 76, 572-577.

Xu Y., Hubal E.C., Clausen P.A. and Little J.C. (2009) Predicting Residential Exposure to Phthalate Plasticizer Emitted from Vinyl Flooring: A Mechanistic Analysis. Environ.Sci.Technol. 43, 2347-2380.

Jensen K.A., Koponen I.K., Clausen P.A. and Schneider T. (2009) Dustiness behavior of loose and compacted bentonite and organoclay powders: What is the difference in exposure risk? Journal of Nanoparticle Research 11, 133-146.

Clausen P.A., Knudsen H.N., Larsen K., Kofoed-Sørensen V., Wolkoff P. and Wilkins C.K. (2008) Use of thermal desorption gas chromatography olfactometry/mass spectrometry (TD-GC-O/MS) for comparison of identified and unidentified odor active compounds emitted from building products containing linseed oil. J. Chromatogr. A 1210, 203-211.

Wolkoff P., Clausen P.A., Larsen K., Hammer M., Larsen S.T. and Nielsen G.D. (2008) Acute airway effects of ozone-initiated d-limonene chemistry: Importance of gaseous products. Toxicol. Lett. 181, 171-176.

Nørgaard A.W., Nøjgaard J.K., Clausen P.A. and Wolkoff P. (2008) Secondary ozonides of substituted cyclohexenes: A new class of pollutants characterized by collision-induced dissociation mass spectrometry using negative chemical ionization. Chemosphere 70, 2032-2038.

Wilkins C.K., Wolkoff P., Knudsen H.N. and Clausen P.A. (2007) The impact of information on perceived air quality - 'organic' vs. 'synthetic' building materials. Indoor Air 17, 130-134.

Larsen S.T., Hansen J.S., Hansen E.W., Clausen P.A. and Nielsen G.D. (2007) Airway inflammation and adjuvant effect after repeated airborne exposures to di-(2-ethylhexyl) phthalate and ovalbumin in BALB/c mice. Toxicology 235, 119-129.

Knudsen H.N., Clausen P.A., Wilkins C.K. and Wolkoff P. (2007) Sensory and chemical evaluation of odorous emissions from building products with and without linseed oil. Build. Environ. 42, 4059-4067.

Clausen P.A. , Xu Y., Kofoed-Sørensen V., Little J.C. and Wolkoff P. (2007) The influence of humidity on the emission of di-(2-ethylhexyl) phthalate (DEHP) from vinyl flooring in the emission cell "FLEC". Atmos. Environ. 41, 3217-3224.

Schneider T., Jensen K.A., Clausen P.A., Afshari A., Gunnarsen L., Wåhlin P., Glasius M., Palmgren F., Nielsen O.J. and Fogh C.L. (2004) Prediction of indoor concentration of 0.5-4 µm particles of outdoor origin in an uninhabited apartment. Atmos. Environ. 38, 6349-6359.

Clausen P.A., Hansen V., Gunnarsen L., Afshari A. and Wolkoff P. (2004) Emission of di(2-ethylhexyl) phthalate from PVC into air and dust. Emission and sorption experiments. Environ Sci Technol. 38, 2531-2537.

Wilkins C.K., Wolkoff P., Clausen P.A., Hammer M. and Nielsen G.D. (2003) Upper airway irritation of terpene/ozone oxidation products (TOPS). Dependence on reaction time, relative humidity and initial ozone concentration. Toxicol. Lett. 143, 109-114.

Clausen P.A., Bille R.L.L., Nilsson T., Hansen V., Svensmark B. and Bøwadt S. (2003) Simultaneous extraction of di(2-ethylhexyl)phthalate and non-ionic surfactants from house dust. Concentrations in floor dust from 15 Danish schools. J. Chromatogr. A 986, 179-190.

Rohr A.C., Wilkins C.K., Clausen P.A., Hammer M., Nielsen G.D., Wolkoff P. and Spengler J.D. (2002) Upper airway and pulmunary effects of oxidation products of (+)-a-pinene, d-limonene, and isoprene in BALB/c mice. Inhalation Toxicology 14, 663-684.

Klenø J.G., Clausen P.A., Weschler C.J. and Wolkoff P. (2001) Determination of ozone removal rates by selected building products using the FLEC emission cell. Environ. Sci. Technol. 35, 2548-2553.

Clausen P.A., Wilkins C.K., Wolkoff P. and Nielsen G.D. (2001) Chemical and biological evaluation of a reaction mixture of R-(+)-limonene/ozone: Formation of strong airway irritants. Environ. Int. 26, 511-522.

Ansættelser

1986 Forskningsassistent, Arbejdsmiljøinstituttet.

1987 Forsker, Arbejdsmiljøinstituttet.

1996 Senior Forsker, Arbejdsmiljøinstituttet.

2007 Senior Forsker, Det Nationale Forskningscenter for Arbejdsmiljø.

2009 Adjungeret lektor ved Kemisk Institut, Københavns Universitet  

Uddannelse