FreeTextSearch
 
search Change language (Se den danske version af denne side)
 
 
 

19p13.3-GADD45B common variants and 19q13.3-PPP1R13L and 19q13.3-CD3EAP in lung cancer risk among Chinese [Epub ahead of print]

Hou W, Yin J, Vogel U, et al. 19p13.3-GADD45B common variants and 19q13.3-PPP1R13L and 19q13.3-CD3EAP in lung cancer risk among Chinese [Epub ahead of print]. Chemico-Biological Interactions 2017;
Date: 2017
Scientific Article
Lung cancer is the most common cause of cancer-related mortality worldwide. The GADD45 gene family plays important roles in a variety of the responses to cell injury including cell cycle checkpoints, apoptosis, DNA repair and anti-tumor immunity. The 19p13.3-GADD45B encoded protein product is involved in apoptosis and inhibiting tumor growth. To evaluate the association of 19p13.3-GADD45B common variants and lung cancer risk, the present study containing 544 Chinese lung cancer cases and 550 cancer-free controls was conducted. Three htSNPs (Haplotpe-tagging single nucleotide polymorphism) (rs7354, rs14383, and rs3783501) covering 95% of the common haplotype diversity in 19p13.3-GADD45B and interaction of 19p13.3-GADD45B and 19q13.3-PPP1R13L and 19q13.3-CD3EAP variants and smoking-duration were explored. Genotype and allele frequencies and haplotype distributions of the 19p13.3-GADD45B 3 htSNPs were not associated with lung cancer risk after adjustment for smoking status. 19p13.3-GADD45B rs7354 was associated with lung cancer risk among
Link: http://dx.doi.org/10.1016/j.cbi.2017.08.018
Orders:
11.09.2017
 
Updated  11.09.2017
Contact: NRCWE web editors
 
Social media buzz on this scientific article

Click the badge for more information on mentions and sharings

The Altmetric service registers social media mentions and sharings of references to scholarly papers, provided the references point to the paper in a recognizable form (publisher's abstract page, DOI-links etc.). The service displays results from selected social media platforms.

If a "?" is displayed within the badge, no mentions or shares have been registered so far.

 
 
 

National Research Centre for the Working Environment | Lersø Parkallé 105 | DK-2100 Copenhagen O | Denmark |

Phone +45 3916 5200 | fax +45 3916 5201 | e-mail: nfa@arbejdsmiljoforskning.dk | CVR: 15413700 | EAN: 5798000399518

Vis desktop version
|WEBSITET ANVENDER COOKIES TIL AT HUSKE DIG OG DINE INDSTILLINGER.| Læs mere her