FreeTextSearch
 
search Change language (Se den danske version af denne side)
 
 
 

Cardiorespiratory fitness, fatness and incident diabetes

Holtermann A, Gyntelberg F, Bauman A, et al. Cardiorespiratory fitness, fatness and incident diabetes. Diabetes Research and Clinical Practice 2017;134:113-20.
Date: 2017
Scientific Article
AIMS: Increases in prevalence have led to a diabetes pandemic. Obesity and low cardiorespiratory fitness (CRF) are considered to be central mechanisms. We investigated if the effect of CRF on diabetes risk was equivalent across levels of fatness among healthy men. METHODS: In total 4,988 middle-aged Caucasian employed men free of cardiovascular disease, diabetes and cancer were included from the Copenhagen Male Study starting in 1970-71. CRF was assessed using a sub-maximal bicycle ergometer test and body mass index (BMI) was measured by height and weight. Their interaction and stratified associations with diabetes incidence were estimated in multivariable Cox-models including conventional risk factors and social class. Diabetes incidence was assessed through a national register. RESULTS: During 44 years of follow-up, 518 (10.4%) incident cases of diabetes occurred. In the multi-adjusted model, the obese had a significantly higher risk of diabetes compared to normal weight men (Hazard Ratio (HR):4.89; 95%CI: 3.62-6.61) and CRF was significantly inversely associated with diabetes (HR:0.86; 95%CI:0.75-0.98 per 10-unit increase in ml/kg/min1 CRF). A significant multi-adjusted interaction between CRF, BMI and diabetes was found (p=0.009). The stratified multi-adjusted analyses on BMI showed a significantly stronger reduced risk of diabetes per 10-unit increase in ml/kg/min1 of CRF among the obese (HR:0.58; CI:0.38-0.89), but a weaker association among overweight (HR:0.86; CI:0.71-1.03) and normal weight (HR:0.97; CI:0.76-1.23). CONCLUSION: High CRF has a stronger protective effect on diabetes among obese than among normal weight men, supporting the recommendation of fitness-enhancing physical activity for preventing diabetes among the obese
Link: http://dx.doi.org/10.1016/j.diabres.2017.10.001
Orders:
26.10.2017
 
Updated  26.10.2017
Contact: NRCWE web editors
 
Social media buzz on this scientific article

Click the badge for more information on mentions and sharings

The Altmetric service registers social media mentions and sharings of references to scholarly papers, provided the references point to the paper in a recognizable form (publisher's abstract page, DOI-links etc.). The service displays results from selected social media platforms.

If a "?" is displayed within the badge, no mentions or shares have been registered so far.

 
 
 

National Research Centre for the Working Environment | Lersø Parkallé 105 | DK-2100 Copenhagen O | Denmark |

Phone +45 3916 5200 | fax +45 3916 5201 | e-mail: nfa@arbejdsmiljoforskning.dk | CVR: 15413700 | EAN: 5798000399518

Vis desktop version
|WEBSITET ANVENDER COOKIES TIL AT HUSKE DIG OG DINE INDSTILLINGER.| Læs mere her