FreeTextSearch
 
search Change language (Se den danske version af denne side)
 
 
 

Maternal hypothyroidism in the perinatal period and childhood asthma in the offspring [Epub ahead of print]

Liu X, Andersen SL, Olsen J, et al. Maternal hypothyroidism in the perinatal period and childhood asthma in the offspring [Epub ahead of print]. Allergy 2017;
Date: 2017
Scientific Article
BACKGROUND: There is increasing interest in the possible link between maternal hypothyroidism in the perinatal period and childhood asthma risk. We explored this in the present study while accounting for the timing of hypothyroidism diagnosis. Further, we evaluated whether the risk was moderated by thyroid hormone treatment during pregnancy. METHODS: We conducted a population-based cohort study using Danish national registers. All liveborn singletons in Denmark from 1998 to 2007 were identified. Maternal hypothyroidism and asthma in the children were defined by data from the Patient Register and Prescription Registry. We estimated incidence rate ratios (IRRs) of asthma among children born to hypothyroid mothers versus children born to mothers with no recorded thyroid dysfunction using Poisson regression models. RESULTS: Of 595,669 children, 3,524 children were born to mothers with hypothyroidism diagnosed before delivery and 4,664 diagnosed after delivery. Overall 48,990 children received treatment for asthma. The IRRs of asthma was 1.16 (95% confidence interval (CI): 1.03-1.30) and 1.12 (95% CI: 1.02-1.24) for children born to mothers with hypothyroidism diagnosed before and after delivery, compared to children born to mothers with no thyroid dysfunction. The highest risk was observed among children born to mothers with hypothyroidism diagnosed before delivery who did not receive thyroid hormone treatment during pregnancy (IRR=1.37, 95% CI: 1.04-1.80). CONCLUSION: Our findings suggest that maternal hypothyroidism, especially when it is untreated, increases childhood asthma risk. Early detection and appropriate treatment of hypothyroidism in pregnant women may be an area for possible prevention of childhood asthma. This article is protected by copyright. All rights reserved
Link: http://dx.doi.org/10.1111/all.13365
Orders:
30.11.2017
 
Updated  30.11.2017
Contact: NRCWE web editors
 
Social media buzz on this scientific article

Click the badge for more information on mentions and sharings

The Altmetric service registers social media mentions and sharings of references to scholarly papers, provided the references point to the paper in a recognizable form (publisher's abstract page, DOI-links etc.). The service displays results from selected social media platforms.

If a "?" is displayed within the badge, no mentions or shares have been registered so far.

 
 
 

National Research Centre for the Working Environment | Lersø Parkallé 105 | DK-2100 Copenhagen O | Denmark |

Phone +45 3916 5200 | fax +45 3916 5201 | e-mail: nfa@arbejdsmiljoforskning.dk | CVR: 15413700 | EAN: 5798000399518

Vis desktop version
|WEBSITET ANVENDER COOKIES TIL AT HUSKE DIG OG DINE INDSTILLINGER.| Læs mere her