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Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

Dudele A, Hougaard KS, Kjølby M, et al. Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner. International Journal of Obesity 2017;41(9):1420-6.
Date: 2017
Scientific Article
BACKGROUND/OBJECTIVES: The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice. METHODS: We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes. RESULTS: Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood. CONCLUSIONS: This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies
Link: http://dx.doi.org/10.1038/ijo.2017.136
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31.12.2017
 
Updated  31.12.2017
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